The Centre for Brain Research was established as an autonomous, non-profit research organization in the Indian Institute of Science under the Karnataka Societies Registration Act of 1960, with the generous gift from Dr. Kris Gopalakrishnan (co-founder of Infosys Limited) and Mrs. Sudha Gopalakrishnan. CBR is funded by philanthropy and receives research grants for specific projects from several granting agencies.                                      Dr. Kris Gopalakrishnan has also provided funds for the construction of the state-of-art building for use by CBR within IISc campus. The philanthropic gift by Dr. Gopalakrishnan is the largest support provided by an individual for scientific research in the history of India.

This is a unique initiative in the current research environment in India that will help in conducting cutting edge research on aging brain and age-associated brain disorders.

Research and Innovation Highlights

Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.

The precise temporal coordination of neural activity is crucial for […]

Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease

Parkinson’s disease (PD) is a debilitating neurodegenerative movement disorder. The […]

Impairment in recall memory after contextual fear conditioning depends on sex and age of APP/PS1 mice

Women living with Alzheimer’s disease (AD) is greater than men, […]

Memory impairment after transient vasoconstriction in mice

Dementia is a major public health concern in aging population. […]

Overload of irrelevant information interferes with new learning in a mouse model of Alzheimer’s disease

Earlier studies have demonstrated that memory dysfunction during early Alzheimer’s […]

The genetic basis of inherited traits and complex disorders

Dr Kahali’s lab has developed efficient human whole genome sequencing […]

Epitranscriptome-mediated regulation of synaptic protein synthesis

Making new proteins ‘as and when required’ is an important […]

CBR-SANSCOG & CBR-TLSA – longitudinal cohort studies to identify risk factors for dementia in India

Comparison of dementia prevalence between rural and urban Indians. Dementia […]