Centre for Brain Research, IISc

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Vivek Tiwari

Vivek Tiwari, PhD
Assistant Professor at the Centre for Brain Research

Profile:

I obtained my masters in Biochemistry from Department of Biochemistry, University of Hyderabad in the year 2008 and PhD from CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India in 2014. My PhD was focused on understanding neurotransmitter energetic in mouse model of Alzheimer’s disease using Nuclear Magnetic Resonance Spectroscopy. I was a Postdoctoral fellow in the duration of 2014-2019 at Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. My postdoctoral work involved development and application of in vivo magnetic resonance spectroscopy (MRS) and imaging methods to understand human brain functions and metabolic alterations in gliomas.

Research

Major theme of my laboratory at Centre for Brain Research is to employ in vivo Magnetic Resonance Spectroscopy (MRS) and imaging (MRI) for understanding brain metabolism together with genetic and epigenetic studies for patient stratification, improved diagnosis, and monitoring of treatment response in brain diseases, particularly neurodegenerative disorders and glioblastomas. I believe cellular functions are the result of interactions between metabolome, epigenome, genome and neurovascular activities. I believe biochemical reactions in the living system maintain the cellular homeostasis. Diseased cells may reprogram metabolism and that may remodel the epigenome and genome. Targeting and quantifying metabolic changes noninvasively in human brain would be a powerful approach to facilitate diagnosis and evaluate therapeutic responses.
Specifically, my laboratory will focus on molecule tailored in vivo 1H and 13C MRS, resting state and activity based functional-MRI in the human brain together with understanding epigenetic and genetic alterations in tissue biopsies for improved Alzheimer’s and glioblastoma patient management. In vivo metabolic images obtained from spectroscopic imaging, functional measures using cerebral blood flow measurement (perfusion-based imaging) and blood oxygenation level dependent signals (BOLD) together with diffusion weighted imaging will be used to identify the subtle functional and structural changes in healthy and diseased brain.

research

People

Vivek

Vivek Tiwari, PhD
Assistant Professor at the Centre for Brain Research

Publications

    Selected Publications


    1. Tiwari V, An Z, Wang Y, Choi C. Distinction of the GABA 2.29 ppm resonance using triple refocusing at 3TIn Vivo. Magnetic Resonance in Medicine. 2018; 80(4):1307-1319.


    2. An Z, Tiwari V, Ganji SK, Baxter J, Levy M, Pinho M, Pan E, Maher EA, Patel TR, Mickey B, and Choi C. Echo-planar spectroscopic imaging with dual-readout alternated gradients (DRAG-EPSI) at 7 T: application for 2-hydroxyglutarate imaging in glioma patients. Magnetic Resonance in Medicine. 2018;79(4):1851-1861


    3. Tiwari V, An Z, Ganji SK, Baxter J, Mickey B, Pan E, Maher EA, Pinho M and Choi C. Measurement of Glycine in healthy and tumorous brain by triple-refocusing MRS at 3T In Vivo. NMR Biomedicine 2017; 30: e3747


    4. Tiwari V, Patel AB. Pyruvate Carboxylase and Pentose Phosphate Fluxes are reduced in AβPP-PS1 Mouse Model of Alzheimer's Disease: A 13C NMR Study. J. Alzheimer’s Disease. 2014; 41:2, 387-399


    5. Tiwari V, Susmitha A, Patel AB. Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. J. Cerebral Blood Flow and Metabolism. 2013; 33:1523-1531


    6. Tiwari V, Veeraiah P, Subramaniam V, Patel AB. Differential Effects of Ethanol on Regional Glutamatergic and GABAergic Neurotransmitter Pathways in Mouse Brain. J. Neurochemistry. 2013; 128:628-640


    7. Google Scholar Link for all publications


      Awards and Honors

      • Suma Cum Laude Merit Award at 27th Annual Meeting and Symposia of International Society for Magnetic Resonance in Medicine at Montreal, Canada May 11-16, 2019


      • UT Southwestern Postdoc Symposia Award for Highest Scored Abstract at the Annual Postdoc Symposia, UT Southwestern Medical Center, Dallas, Sept 21, 2018


      • Magna Cum Laude Merit Award at 25th Annual Meeting and Symposia of International Society for Magnetic Resonance in Medicine at Hawaii, April 21-27, 2017


      • A.R. Gopala Aiyengar Best Poster Award at Annual Meeting of the Indian Biophysical Society, Chennai, January 2012


      • D.M. Bose Best Poster Award at 7th Asian Biophysics Association Symposium & Annual Meeting of the Indian Biophysical Society, New Delhi, February 2011


Positions

Contact

Centre for Brain Research
SID (Innovation centre) complex
Indian Institute of Science (IISc)
Malleswaram 18th Cross
Bangalore-560012
Karnataka, INDIA.

Email: vivekt[at]iisc.ac.in
Telephone: Office +91 80 2293 3588