Centre for Brain Research, IISc

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Ganesh Chauhan

Ganesh Chauhan, PhD
Assistant Professor at the Centre for Brain Research

Area of expertise: Genetics of complex neurological disorders

Email: ganeshchauhan@iisc.ac.in
Telephone: Office +91 80 2293 3009 | Mobile +91 7899040054

Research

The primary aim of his research is to understand the genetic basis of complex neurological disorders, with a special emphasis on dementia, stroke and cerebral small vessel disease. He uses approaches starting from candidate genes, genome wide association studies to whole genome sequencing using NGS platforms to identify rare and common genetic variants in genes responsible for complex neurological disorders.

He has been leading large scale genome wide association studies and trans-ethnic meta-analysis as part of collaboration within the CHARGE consortium and other large consortia.

Currently he is exploring ways to use NGS methods to understand genetic variations leading to dementia in the Indian population.

People

Ganesh Chauhan

Ganesh Chauhan, PhD
Scientist at the Centre for Brain Research

Publications

Top five publications

  1. Chauhan G, Arnold CR, Chu AY, Fornage M, Reyahi A, Bis JC, Havulinna AS, Sargurupremraj M, Smith AV, Adams HH, Choi SH, Pulit SL, Trompet S, Garcia ME, Manichaikul A, Teumer A, Gustafsson S, Bartz TM, Bellenguez C, Vidal JS, Jian X, Kjartansson O, Wiggins KL, Satizabal CL, Xue F, Ripatti S, Liu Y, Deelen J, Hoed Md, Bevan S, Hopewell JC, Malik R, Heckbert SR, Rice K, Smith NL, Levi C, Sharma P, Sudlow CL, Nik AM, Cole JW, Schmidt R, Meschia J, Thijs V, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wassertheil-Smoller S, Lee J, Wong Q, Aparicio HJ, Engelter ST, Kloss M, Leys D, Pezzini A, Buring JE, Ridker PM, Berr C, Dartigues J, Hamsten A, Magnusson PK, Traylor M, Pedersen NL, Lannfelt L, Lind L, Lindgren CM, Morris AP, Jimenez-Conde J, Montaner J, Radmanesh F, Slowik A, Woo D, Hofman A, Koudstaal PJ, Portegies ML, Uitterlinden AG, De Craen AJ, Ford I, Jukema JW, Stott DJ, Allen NB, Sale MM, Johnson AD, Bennett DA, De Jager PL, White CC, Grabe HJ, Markus MR, Schminke U, Boncoraglio GB, Clarke R, Kamatani Y, Dallongeville J, Lopez OL, Rotter JI, Nalls MA, Gottesman RF, Griswold ME, Knopman DS, Windham BG, Beiser A, Markus HS, Vartiainen E, French CR, Dichgans M, Pastinen T, Lathrop M, Gudnason V, Kurth T, Psaty BM, Harris TB, Rich SS, DeStefano AL, Schmidt CO, Worrall BB, Rosand J, Salomaa V, Mosley TH, Ingelsson E, van Duijn CM, Tzourio C, Rexrode KM, Lehmann OJ, Launer LJ, Ikram MA, Carlsson P, Chasman DI, Childs SJ, Longstreth J, W. T., Seshadri S, Debette S: Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. The Lancet Neurology, 2016
    The largest incident stroke GWAS with comprehensive functional studies

  2. Chauhan G, Debette S: Genetic Risk Factors for Ischemic and Hemorrhagic Stroke. Curr Cardiol Rep 18:124, 2016
    A comprehensive review of genetic risk loci of stroke

  3. Chauhan G, Spurgeon CJ, Tabassum R, Bhaskar S, Kulkarni SR, Mahajan A, Chavali S, Kumar MV, Prakash S, Dwivedi OP, Ghosh S, Yajnik CS, Tandon N, Bharadwaj D, Chandak GR: Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 59:2068-2074, 2010
    First large scale genetic study of T2D from India

  4. Patowary A, Purkanti R, Singh M, Chauhan RK, Bhartiya D, Dwivedi OP, Chauhan G, Bharadwaj D, Sivasubbu S, Scaria V: Systematic analysis and functional annotation of variations in the genome of an Indian individual. Human mutation 33:1133-1140, 2012
    First whole genome sequence of an Indian

  5. Tabassum R*, Chauhan G*, Dwivedi OP*, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T, Mathai BJ, Pandey Y, Chidambaram M, Sharma A, Chavali S, Sengupta S, Ramakrishnan L, Venkatesh P, Aggarwal SK, Ghosh S, Prabhakaran D, Srinath RK, Saxena M, Banerjee M, Mathur S, Bhansali A, Shah VN, Madhu SV, Marwaha RK, Basu A, Scaria V, McCarthy MI, Venkatesan R, Mohan V, Tandon N, Bharadwaj D: Genome-wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21. Diabetes, 2012
    First GWAS of T2D from India

Positions

I am looking for highly motivated research assistants, project students and post-doctoral fellows to work on computational genetics projects. Candidates having prior experience with computational work, statistical courses taken during undergraduate and postgraduate training, having programing experience are encouraged to apply.

Interested candidates are requested to contact the principal investigator Dr. Ganesh Chauhan(ganeshchauhan@iisc.ac.in; bratatis@gmail.com).

Postdoctoral Research Fellow Position Available


Project Assistant Position Available


Contact

Centre for Brain Research
SID (Innovation centre) complex
Indian Institute of Science (IISc)
Malleswaram 18th Cross
Bangalore-560012
Karnataka, INDIA.

Email: ganeshchauhan@iisc.ac.in
Telephone: Office +91 80 2293 3009 | Mobile +91 7899040054