Recent progress and future challenges posed by neurological diseases

Abstract

As longevity is increasing and the society is aging, the burden of neurological diseases continues to grow exponentially. Not only are the neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Amyotrophic diseases a major concern but the incidence of neuroimmune disorders and emerging infectious diseases continues to rise.  Additionally, nearly 70% of undiagnosed diseases are neurological disorders.  While major advancements have been made in developing
disease modifying therapies for acute stroke and some neuroimmune disorders, symptomatic therapy is the main stay of treatment for the vast majority of diseases.  Identification of genetic basis of neurological diseases, raises hope for identifications of new targets for treatment.  However, major advancements in diagnosis and treatment such as CT and MRI scanners and deep brain stimulation have emerged through advancements in engineering and physical sciences.  This interface of applied physics with neurosciences has the potential to transform the way we treat neurological disorders in ways that maybe hard to imagine.